Ketorolac tromethamine — what it does and how to use it safely

If you need a strong pain killer for short-term relief, ketorolac (often called Toradol) is one of the go-to NSAIDs doctors use. It reduces pain and inflammation without the opioid side effects, which is why it's common after surgeries, dental work, or for sudden severe pain. But ketorolac isn't meant for long-term use — it works well for a few days, then you should switch to a safer plan.

What ketorolac is and when it's used

Ketorolac blocks the same enzymes as other NSAIDs to lower pain and swelling. Hospitals use it by injection (IV or IM) for quick relief; oral tablets are also available once the immediate need passes. Typical goals: control moderate-to-severe acute pain when other options aren’t enough and avoid or reduce opioid doses.

Most guidelines limit ketorolac to very short courses. Total treatment—counting both injections and pills—usually should not go beyond 5 days. If pain continues, talk to your prescriber about other options rather than extending ketorolac.

Safety, interactions, and practical tips

Side effects can be serious. Watch for stomach pain, black stools, unusual bruising or bleeding, dizziness, and reduced urine output. These can signal gastrointestinal bleeding, increased bleeding risk, or kidney trouble. People with active peptic ulcers, bleeding disorders, or severe kidney disease should avoid ketorolac.

It interacts with many drugs: blood thinners (warfarin, DOACs), other NSAIDs, corticosteroids, certain antidepressants (SSRIs), and some blood pressure medicines can raise bleeding or kidney risk. Always tell your prescriber about every medicine you take, including over-the-counter pain pills and herbal supplements.

Pregnancy: avoid ketorolac in late pregnancy. It can affect the baby’s circulation and cause problems during delivery. If you’re breastfeeding or pregnant, ask your clinician before taking it.

Practical tips: use the lowest effective dose for the shortest time, avoid mixing with alcohol, and stop the drug and seek help if you notice blood in vomit or stools, severe stomach pain, or sudden shortness of breath. If you miss a dose, skip it—don’t double up.

Buying and prescriptions: ketorolac is prescription-only. If buying online, use a licensed pharmacy that requires a real prescription and shows clear contact info and pharmacy credentials. Avoid sites that sell without asking for a prescription or offer unbranded pills from unknown sources.

Finally, if pain persists beyond a few days or you develop warning signs, contact your healthcare provider. Ketorolac can be very helpful when used correctly, but it needs respect — short course, careful checks, and good communication with your prescriber will keep you safer.